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I got this pdf from one of my friend in facebook and I got this PDF file from her website, it is not legal for us to publish PDF files from website itself. Please send to me if you are in right .Pseudocholinesterase activity in different stages of Schistosoma haematobium infection.
Schistosoma haematobium infection is an important public health problem in several areas of the tropics. Impaired cholinergic anti-inflammatory pathway is associated with chronic inflammation. The aim of this study was to determine whether the balance in phospholipase A(2) (PLA(2)) and cholinesterase (ChE) may be involved in the course of the inflammatory process following S. haematobium infection. We have studied the enzyme activities in serum samples collected from S. haematobium-infected and non-infected individuals, and compared them to those from experimentally infected mice. Using zymography, the authors demonstrated increased PLA(2) and ChE activities in infected patients. Whereas ChE showed a significantly higher activity in samples from S. haematobium-infected patients compared to controls, a slight difference in the levels of PLA(2) activity was observed between the two groups. No significant changes were detected in mice experimentally infected with S. haematobium after a similar treatment period of up to 40 days. These results suggest that an imbalance in cholinergic activity could be involved in S. haematobium-induced inflammation, and that the ChE concentration was more affected than the PLA(2) in S. haematobium-infected individuals.
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